Molecular variants of β2-microglobulin in renal insufficiency
نویسندگان
چکیده
منابع مشابه
Influence of heparin molecular size on the induction of C-terminal unfolding in β2-microglobulin
Dialysis-related amyloidosis (DRA) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. Matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. In clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (H.M.H. and L.M.H.) have been routinely use...
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The deposition of amyloid-like fibrils, composed primarily of the 99-residue protein β2-microglobulin (β2m), is one of the characteristic symptoms of dialysis-related amyloidosis. Fibrils formed in vitro at low pH and low salt concentration share many properties with the disease related fibrils and have been extensively studied by a number of biochemical and biophysical methods. These fibrils c...
متن کاملinfluence of heparin molecular size on the induction of c-terminal unfolding in β2-microglobulin
dialysis-related amyloidosis (dra) is characterized by accumulation of amyloid β2-microglobulin (β2m) in the interstitial matrix. matrix substances such as heparin have reportedly been strongly implicated in the pathogenesis of dialysis-related amyloidosis. in clinical setting of hemodialysis, two types of heparin, i.e., high and low molecular heparin (h.m.h. and l.m.h.) have been routinely use...
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Introduction: Sickle cell nephropathy is a cause of significant morbidity and mortality in patients with sickle cell disease. Traditional creatinine based assay for evaluating renal function has several limitations. Hence, the need for more sensitive markers such as β2 microglobulin (β2M). This study seeks to compare β2M with creatinine as a marker of renal damage in patients with sickle cell d...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1994
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2980181